A NEW SULFUR TRANSFER REAGENT FOR THE SYNTHESIS OF OLIGONUCLEOTIDE PHOSPHOROTHIOATES



  • Soluble and stable in anhydrous acetonitrile

  • Mixed bases 25-mer of DNA phosphorothioates gave less than 1% P=O using 60 second sulfurizing time

  • Smell less crystalline powder with formula weight 195.27


3-phenyl 1,2,4-dithiazoline-5-one* (POS) is a novel sulfurizing reagent, highly soluble and stable in anhydrous acetonitrile.

POS is a yellow crystalline product with no foul smell. 0.15M solution of POS in anhydrous acetonitrile is recommended for the synthesis of DNA phosphorothioates using contact time 60 second.

U.S. Patent #: 6,500,944

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To download the PolyOrg Sulfa Specification Sheet in PDF format, please click here.