A NEW SULFUR TRANSFER REAGENT FOR THE SYNTHESIS OF OLIGONUCLEOTIDE PHOSPHOROTHIOATES
Soluble and stable in anhydrous acetonitrile
Mixed bases 25-mer of DNA phosphorothioates gave less than 1% P=O using 60 second sulfurizing time
Smell less crystalline powder with formula weight 195.27
3-phenyl 1,2,4-dithiazoline-5-one* (POS) is a novel sulfurizing reagent, highly soluble and stable in anhydrous acetonitrile.
U.S. Patent #: 6,500,944