Solving Your Chemical Synthesis Needs

Small Scale Custom Synthesis to Toll Manufacturing

About Us

Founded in 2003, PolyOrg is a Massachusetts-based chemical research organization and chemical manufacturing organization that specializes in the manufacturing of specialty chemical products used in the life science industry.

In addition to offering our 350+ catalog products, we help our customers develop new products, improve existing products, and transition their existing products from research to manufacturing.

We perform contract research, process development, custom synthesis, and manufacturing for clients in various science industries.

Our clients are primarily in the pharmaceutical, biotechnology, specialty chemicals, and diagnostic industries.

We employ expert Ph.D. chemists and process chemists skilled in organic, solid phase, medicinal, natural product, nucleic acid, and polymer chemistry. 

For inquiries or quotation requests, email

Our products


Catalog Products

PolyOrg's main product lines serve the nucleic acid chemistry field. PolyOrg produces high quality oligo synthesis reagents (reagents for the synthesis of RNA and DNA oligonucleotides - natural DNA Phosphoramidites and Supports and Natural RNA Phosphoramidites and Supports). PolyOrg also produces ancillary reagents [activators, capping reagents, deblocking (detritylation) reagents] for oligonucleotide synthesizers. PolyOrg also has expertise in larger scale manufacturing of classic and custom FMOC and BOC protected PNA Monomers. PolyOrg also offers its own novel sulfurizing reagent known as PolyOrg Sulfa. 

Contract Research

PolyOrg, Inc. tailors its synthesis services to the specific requirements of its clients, enabling small and large organizations to address their specific R&D issues. We use innovative approaches for the synthesis to fulfill our client’s requirements. We focus on reducing the time, cost, and safety hazards of the project. Our Full Time Equivalent (FTE) program is ideal for contract research and development.

Custom Synthesis

PolyOrg, Inc. synthesizes compounds either by following procedures supplied by the clients or by researching relevant scientific publications to determine the best synthetic strategy for a given compound. We guarantee confidentiality by establishing a non-disclosure agreement for each project. Our well-documented processes are reinforced with analytical data to ensure that any intellectual property that is developed can be supported for our clients.

Process Development

We explore new routes directed at safer and more economical synthetic approaches. Our chemists design and optimize any step of an existing procedure, regardless of synthesis scale, to improve yields and to increase safety. We also design environmentally friendly processes for the synthesis.